２０１9年

Furukawa K, Ohmi Y, Ohkawa Y, Bhuiyan RH, Zhang P, Tajima O, Hashimoto N, Hamamura K, Furukawa K.
New era of research on cancer-associated glycosphingolipids.
Cancer Sci. 2019 May;110(5):1544-1551. doi: 10.1111/cas.14005. Epub 2019 Apr 29.Cancer Sci. 2019. PMID: 30895683 Free PMC article. Review.

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Hamamura K, Hamajima K, Yo S, Mishima Y, Furukawa K, Uchikawa M, Kondo Y, Mori H, Kondo H, Tanaka K, Miyazawa K, Goto S, Togari A.
Deletion of GD3 Synthase in Mice Resulted in the Attenuation of Bone Formation via Decrease inOsteoblasts.
Int J Mol Sci. 2019 Sep 18;20(18):4619. doi: 10.3390/ijms20184619.Int J Mol Sci. 2019. PMID: 31540393 Free PMC article.

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Tian S, Muneeruddin K, Choi MY, Tao L, Bhuiyan RH, Ohmi Y, Furukawa K, Furukawa K, Boland S, Shaffer SA, Adam RM, Dong M.
Genome-wide CRISPR screens for Shiga toxins and ricin reveal Golgi proteins critical for glycosylation.
PLoS Biol. 2018 Nov 27;16(11):e2006951. doi: 10.1371/journal.pbio.2006951. eCollection 2018 Nov.PLoS Biol. 2018. PMID: 30481169 Free PMC article.

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Yo S, Hamamura K, Mishima Y, Hamajima K, Mori H, Furukawa K, Kondo H, Tanaka K, Sato T, Miyazawa K, Goto S, Togari A.
Deficiency of GD3 Synthase in Mice Resulting in the Attenuation of Bone Loss with Aging.
Int J Mol Sci. 2019 Jun 10;20(11). pii: E2825. doi: 10.3390/ijms20112825.

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Hashimoto N, Ito S, Tsuchida A, Bhuiyan RH, Okajima T, Yamamoto A, Furukawa K, Ohmi Y, Furukawa K.
The ceramide moiety of disialoganglioside (GD3) is essential for GD3 recognition by the sialic acid-binding lectin SIGLEC7 on the cell surface.
J Biol Chem. 2019 Jul 12;294(28):10833-10845. doi: 10.1074/jbc.RA118.007083. Epub 2019 May 28.

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Furukawa K, Ohmi Y, Ohkawa Y, Bhuiyan RH, Zhang P, Tajima O, Hashimoto N, Hamamura K, Furukawa K.
New era of research on cancer-associated glycosphingolipids.
Cancer Sci. 2019 May;110(5):1544-1551. doi: 10.1111/cas.14005. Epub 2019 Apr 29. Review.

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Furukawa K, Ohmi Y, Kondo Y, Bhuiyan RH, Tajima O, Zhang P, Ohkawa Y, Furukawa K.
Elucidation of the enigma of glycosphingolipids in the regulation of inflammation and degeneration - Great progress over the last 70 years.
Proc Jpn Acad Ser B Phys Biol Sci. 2019;95(3):136-149. doi: 10.2183/pjab.95.011.Review.

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Orimo T, Sasaki I, Hemmi H, Ozasa T, Fukuda-Ohta Y, Ohta T, Morinaka M, Kitauchi M, Yamaguchi T, Sato Y, Tanaka T, Hoshino K, Katayama KI, Fukuda S, Miyake K, Yamamoto M, Satoh T, Furukawa K, Kuroda E, Ishii KJ, Takeda K, Kaisho T.
Cholera toxin B induces interleukine-1β production from resident peritoneal macrophages through pyrin as well as NLRP3 inflammasome.
Int Immunol. 2019 Jan 25. doi: 10.1093/intimm/dxz004. [Epub ahead of print]

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Bhuiyan RH, Ohmi Y, Ohkawa Y, Zhang P, Takano M, Hashimoto N, Okajima T, Furukawa K, Furukawa K.

Loss of Enzyme Activity in Mutated B4GALNT1 Gene Products in Patients with Hereditary Spastic Paraplegia Results in Relatively Mild Neurological Disorders: Similarity with Phenotypes of B4galnt1 Knockout Mice.

Neuroscience. 2019 Jan 15;397:94-106. doi: 10.1016/j.neuroscience.2018.11.034. Epub 2018 Dec 4.

２０１8年

Tian S, Muneeruddin K, Choi MY, Tao L, Bhuiyan RH, Ohmi Y, Furukawa K, Furukawa K, Boland S, Shaffer SA, Adam RM, Dong M.

Genome-wide CRISPR screens for Shiga toxins and ricin reveal Golgi proteins critical for glycosylation.

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Ohmi Y, Kambe M, Ohkawa Y, Hamamura K, Tajima O, Takeuchi R, Furukawa K, Furukawa K.

Differential roles of gangliosides in malignant properties of melanomas.

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Liu HN, Hirata H, Okuno Y, Okabe M, Furukawa K.

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Kondo Y, Fu J, Wang H, Hoover C, McDaniel JM, Steet R, Patra D, Song J, Pollard L, Cathey S, Yago T, Wiley G, Macwana S, Guthridge J, McGee S, Li S, Griffin C, Furukawa K, James JA, Ruan C, McEver RP, Wierenga KJ, Gaffney PM, Xia L.

Site-1 protease deficiency causes human skeletal dysplasia due to defective inter-organelle protein trafficking.

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Furukawa K, Ohmi Y, Tajima O, Ohkawa Y, Kondo Y, Shuting J, Hashimoto N, Furukawa K.

Gangliosides in Inflammation and Neurodegeneration.

Iwasawa T, Zhang P, Ohkawa Y, Momota H, Wakabayashi T, Ohmi Y, Bhuiyan RH, Furukawa K, Furukawa K.

Enhancement of malignant properties of human glioma cells by ganglioside GD3/GD2.

２０１７年

Esaki N, Ohkawa Y, Hashimoto N, Tsuda Y, Ohmi Y, Bhuiyan RH, Kotani N, Honke K, Enomoto A, Takahashi M, Furukawa K, Furukawa K.
ASCT2 defined by enzyme-mediated activation of radical sources enhances malignancy of GD2-plus small cell lung cancer.

Furukawa K, Ohmi Y, Ji S, Zhang P, Bhuiyan RH, Ohkawa Y, Tajima O, Hashimoto N, Furukawa K.
Glycolipids: Essential regulator of neuro-inflammation, metabolism and gliomagenesis.

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Nogimori K, Hori T, Kawaguchi K, Fukui T, Mii S, Nakada H, Matsumoto Y, Yamauchi Y, Takahashi M, Furukawa K, Tetsuya O, Yokoi K, Hasegawa Y, Furukawa K.

[Corrigendum] Increased expression levels of ppGalNAc-T13 in lung cancers: Significance in the prognostic diagnosis.
Int J Oncol. 2017 Feb;50(2):746. doi: 10.3892/ijo.2016.3796. Epub 2016 Dec 7.

 

２０１６年

Yamaguchi T, Yamauchi Y, Furukawa K, Ohmi Y, Ohkawa Y, Zhang Q, Okajima T, Furukawa K.

Expression of B4GALNT1, an essential glycosyltransferase for the synthesis of complex gangliosides, suppresses BACE1 degradation and modulates APP processing.
Sci Rep. 2016 Sep 30;6:34505. doi: 10.1038/srep34505.

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Ji S, Tokizane K, Ohkawa Y, Ohmi Y, Banno R, Okajima T, Kiyama H, Furukawa K, Furukawa K.

Increased a-series gangliosides positively regulate leptin/Ob receptor-mediated signals in hypothalamus of GD3 synthase-deficient mice.

Biochem Biophys Res Commun. 2016 Sep 16. pii: S0006-291X(16)31537-6. doi: 10.1016/j.bbrc.2016.09.077.

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Nogimori K, Hori T, Kawaguchi K, Fukui T, Mii S, Nakada H, Matsumoto Y, Yamauchi Y, Takahashi M, Furukawa K, Tetsuya O, Yokoi K, Hasegawa Y, Furukawa K.

Increased expression levels of ppGalNAc-T13 in lung cancers: Significance in the prognostic diagnosis.

Int J Oncol. 2016 Oct;49(4):1369-76. doi: 10.3892/ijo.2016.3638. Epub 2016 Jul 29.

 

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Furukawa K.

Molecular dynamics and regulatory mechanisms for signals of glycosphingolipids in membrane lipid rafts

Seikagaku. 2016 Jun;88(3):369-79. Japanese.

 

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Kaneko K, Ohkawa Y, Hashimoto N, Ohmi Y, Kotani N, Honke K, Ogawa M, Okajima T, Furukawa K, Furukawa K.

Neogenin defined as a GD3-associated molecule by enzyme-mediated activation of radical sources confers malignant properties via intra-cytoplasmic domain in melanoma cells.

J Biol Chem. 2016 Aug 5;291(32):16630-43. doi: 10.1074/jbc.M115.708834. Epub 2016 Jun 10.

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Matsumoto T, Takahashi N, Kojima T, Yoshioka Y, Ishikawa J, Furukawa K, Ono K, Sawada M, Ishiguro N, Yamamoto A.

Soluble Siglec-9 suppresses arthritis in a collagen-induced arthritis mouse model and inhibits M1 activation of RAW264.7 macrophages.

Arthritis Res Ther. 2016 Jun 7;18(1):133. doi: 10.1186/s13075-016-1035-9.

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Bhuiyan RH, Kondo Y, Yamaguchi T, Tokuda N, Ohkawa Y, Hashimoto N, Ohmi Y, Yamauchi Y, Furukawa K, Okajima T, Furukawa K.

Expression analysis of 0-series gangliosides in human cancer cell lines with monoclonal antibodies generated using knockout mice of ganglioside synthase genes.

Glycobiology. 2016 Apr 21.

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Makino Y, Hamamura K, Takei Y, Bhuiyan RH, Ohkawa Y, Ohmi Y, Nakashima H, Furukawa K, Furukawa K.

A therapeutic trial of human melanomas with combined small interfering RNAs targeting adaptor molecules p130Cas and paxillin activated under expression of ganlioside GD3

Biochim Biophys Acta. 2016 Aug;1860(8):1753-63. doi: 10.1016/j.bbagen.2016.04.005. Epub 2016 Apr 9.

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Ohmi Y, Ise W, Harazono A, Takakura D, Fukuyama H, Baba Y, Narazaki M, Shoda H, Takahashi N, Ohkawa Y, Ji S, Sugiyama F, Fujio K, Kumanogoh A, Yamamoto K, Kawasaki N, Kurosaki T, Takahashi Y, Furukawa K,

Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis

Nat Commun. 2016 Apr 5;7:11205. doi: 10.1038/ncomms11205.

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Komura N, Suzuki KG, Ando H, Konishi M, Koikeda M, Imamura A, Chadda R, Fujiwara TK, Tsuboi H, Sheng R, Cho W, Furukawa K, Furukawa K, Yamauchi Y, Ishida H, Kusumi A, Kiso M,

Raft-based interactions of gangliosides with a GPI-anchored receptor.

Nat Chem Biol. 2016 Jun;12(6):402-10. doi: 10.1038/nchembio.2059. Epub 2016 Apr 4.

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Waguri N, Osaki A, Ikarashi S, Ogawa M, Kuraoka N, Ogawa K, Sato M, Aiba T, Yoneyama O, Furukawa K, Sugimura K, Igarashi K, Simultaneous combined balloon-occluded retrograde transvenous obliteration and partial splenic embolization for gastric fundal varices, United European Gastroenterol J. 4(1), 62-9, 2016, doi:10.1177/2050640615581966.

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McGonigal R, Cunningham ME, Yao D, Barrie JA, Sankaranarayanan S, Fewou SN, Furukawa K, Yednock TA, Willison HJ, C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy, Acta Neuropathol Commun. 4(1), 23, 2016, doi:10.1186/s40478-016-0291-x.

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Ando R, Tokuda N, Yamamoto T, Ikeda K, Hashimoto N, Taguchi R, Fan X, Furukawa K, Niimura Y, Suzuki A, Goto M, Furukawa K, Immunization of A4galt-deficient mice with glycosphingolipids from renal cell cancers resulted in the generation of anti-sulfoglycolipid monoclonal antibodies, Glycoconj J, 33(2), 169-80, 2016, doi:10.1007/s10719-016-9654-6.

 

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Ishikawa J, Takahashi N, Matsumoto T, Yoshioka Y, Yamamoto N, Nishikawa M, Hibi H, Ishigro N, Ueda M, Furukawa K, Yamamoto A. Factors secreted from dental pulp stem cells show multifaceted benefits for treating experimental rheumatoid arthritis, Bone. 83, 210-9, 2016, doi: 10.1016/j.bone.2015.11.012.　

 

 

２０１５年

Hattori T, Watanabe-Takahashi M, Ohoka N, Hamabata T, Furukawa K, Nishikawa K, Naito M. Proteasome inhibitors prevent cell death and prolong survival of mice challenged by Shiga toxin, FEBS Open Bio. 5, 605-14, 2015, doi: 10.1016/j.fob.2015.06.005.

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Yamauchi Y, Iwamoto N, Rogers MA, Abe-Dohmae S, Fujimoto T, Chang CC, Ishigami M, Kishimoto T, Kobayashi T, Ueda K, Furukawa K, Chang TY, Yokoyama S, Dificiency in the lipid exporter ABCA1 impairs retrograde sterol movement and disrupts sterol sensing at the Endoplasmic reticulum, J Biol Chem. 290(39), 23464-77, 2015, doi: 10.1074/jbc.M115.662668.

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Ohkawa Y, Momota H, Kato A, Hashimoto N, Tsuda Y, Kotani N, Honke K, Suzumura A, Furukawa K, Ohmi Y, Natsume A, Wakabayashi T, Furukawa K. Ganglioside GD3 enhances invasiveness of gliomas by forming a complex with platelet-derived growth factor receptor alpha and Yes, J Biol Chem. 290(26),16043-58, 2015, doi: 10.1074/jbc.M114.635755.

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Ogawa M, Sawaguchi S, Kawai T, Nadano D, Matsuda T, Yagi H, Kato K, Furukawa K, Okajima T. Impaired O-linked N-acetylglucosaminylation in the endoplasmic reticulum by mutated epidermal growth factor (EGF) domain-specific O-linked N-acetylglucosamine transferase found in Adams-Oliver syndrome, J Biol Chem. 290 (4), 2137-49, 2015, doi: 10.1074/jbc.M114.598821.

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Matsubara K, Matsushita Y, Sakai K, Kano F, Kondo M, Noda M, Hashimoto N, Imagama S, Ishiguro N, Suzumura A, Ueda M, Furukawa K, Yamamoto A. Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte chemoattractant protein-1 promote recovery after rat spinal cord injury by altering macrophage polarity, J Neurosci. 35, (6), 2452-64, 2015, doi: 10.1523/JNEUROSCI.4088-14.

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Ji S, Ohkawa Y, Tokizane K, Ohmi Y, Banno R, Furukawa K, Kiyama H, Furukawa K. b-Series gangliosides crucially regulate leptin secretion in adipose tissues, Biochem Biophys Res Commun. 459 (2), 189-95, 2015, doi: 10.1016/j.bbrc.2015.01.143.

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Yamamura Y, Asai N, Enomoto A, Kato T, Mii S, Kondo Y, Ushida K, Niimi K, Tsunoda N, Nagino M, Ichihara S, Furukawa K, Maeda K, Murohara T, Takahashi M. Akt-Girdin signaling in cancer-associated fibroblasts contributes to tumor progression, Cancer Res. 75 (5), 813-23, 2015, doi: 10.1158/0008-5472.CAN-14-1317.

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Furukawa K, Matsumoto Y, Zhang Q, Furukawa K. Gangliosides Regulate Tumor Properties: With Focus on the Suppression of Metastasis-Associaated ppGalNAc-T13 with GM1, In Sugar Chains Chapter 4, Eds by Suzuki T, Springer, 2015, in press

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総説
Furukawa K, Ohmi Y, Kondo Y, Ohkawa Y, Tajima O, Furukawa K. Regulatory function of glycosphingolipids in the inflammation and degeneration, Arch Biochem Biophys. 571, 58-65, 2015, doi: 10.1016/j.abb.2015.02.007.

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総説
Ogawa M, Sawaguchi S, Furukawa K, Okajima T. N-acetylglucosamine modification in the lumen of the endoplasmic reticulum., Biochim Biophys Acta. 1850 (6), 1319-1324, 2015, doi: 10.1016/j.bbagen.2015.03.003.

 

２０１４年

Sha S, Zhou L, Yin J, Takamiya K, Furukawa K, Furukawa K, Sokabe M, Chen L. Deficits in cognitive function and hippocampal plasticity in GM2/GD2 synthase knockout mice, Hippocampus. 24 (4), 369-82, 2014.

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Kato T, Enomoto A, Watanabe T, Haga H, Ishida S, Kondo Y, Furukawa K, Urano T, Mii S, Weng L, Ishida-Takagishi M, Asai M, Asai N, Kaibuchi K, Murakumo Y, Takahashi M. TRIM27/MRTF-B-dependent integrin β1 expression defines leading cells in cancer cell collectives, Cell Rep. 7 (4), 1156-67, 2014, doi: 10.1016/j.celrep.2014.03.068.

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Furukawa K, Kambe M, Miyata M, Ohkawa Y, Tajima O, Furukawa K. Ganglioside GD3 induces convergence and synergism of adhesion and hepatocyte growth factor/Met signals in melanomas, Cancer Sci. 105 (1), 52-63, 2014, doi: 10.1111/cas.12310.

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Yao D, McGonigal R, Barrie JA, Cappell J, Cunningham ME, Meehan GR, Fewou SN, Edgar JM, Rowan E, Ohmi Y, Furukawa K, Furukawa K, Brophy PJ,Willison HJ. Neuronal expression of GalNAc transferase is sufficient to prevent the age-related neurodegenerative phenotype of complex ganglioside-deficient mice, J Neurosci. 34 (3), 880-91, 2014, doi: 10.1523/JNEUROSCI.3996-13.2014

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Furukawa K, Ohmi Y, Kondo Y, Ohkawa Y, lashimoto N, Tajima O, Furukawa K. The role of glycolipids in lipid rafts: lessons from knockout mice, In Lipid Rafts: Properties, controversies and roles in signal transduction. Ed. By Dan Sillence, pp1-20, Nova Science Publishers, London, 2014

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Ohmi Y, Ohkawa Y, Tajima O, Sugiura Y, Furukawa K, Furukawa K. Ganglioside deficiency causes inflammation and neurodegeneration via the activation of complement system in the spinal cord, J Neuroinflammation. 11, 61, 2014, doi: 10.1186/1742-2094-11-61.

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Miyata M, Ichihara M, Tajima O, Sobue S, Kambe M, Sugiura K, Furukawa K, Furukawa K. UVB-irradiated keratinocytes induce melanoma-associated ganglioside GD3 synthase gene in melanocytes via secretion of tumor necrosis factor α and interleukin 6, Biochem Biophys Res Commun. 445 (2), 504-10, 2014, doi: 10.1016/j.bbrc.2014.02.038.

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Furukawa K, Ohmi Y, Ohkawa Y, Hashimoto N, Yamauchi Y, Tajima O, Furukawa K. Ganglioside, synthesis and function in nervous tissues, In Glycoscience: Biology and Medicine Eds by Taniguchi N, Endo T, Hart G, Seeberger P, Wong C.-H, Springer, New Delhi, 2014

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Furukawa K, Ohmi Y, Ohkawa Y, Tajima O, Furukawa K. Glycosphingo-lipids in the regulation of the nervous system, In glycobiology of the Nervous system. EDS by Yu R K, and Shengrund C. –L. Springer, Publishing, 2014

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総説
Ogawa M, Furukawa K, Okajima T. Extracellular O-linked β-N-acetylglucosamine: Its biology and relationship to human disease, World J Biol Chem. 5 (2), 224-30, 2014, doi: 10.4331/wjbc.v5.i2.224.

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総説
Furukawa K, Ohmi Y, Ohkawa Y, Tajima O, Furukawa K. Glycosphingolipids in the regulation of the nervous system, Adv Neurobiol. 9, 307-20, 2014, doi: 10.1007/978-1-4939-1154-7_14.

 

２０１３年

Hotta H, Hamamura K, Yamashita K, Shibuya H, Tokuda N, Hashimoto N, Furukawa K, Yamamoto N, Hattori H, Toyokuni S, Ueda M, Furukawa K. Lewis y antigen is expressed in oral squamous cell carcinoma cell lines and tissues, but disappears in the invasive regions leading to the enhanced malignant properties irrespective of sialyl-Lewis x. Glycoconj J.30 (6), 585-97, 2013, doi: 10.1007/s10719-012-9458-2.

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Tokuda N, Numata S, Li X, Nomura T, Takizawa M, Kondo Y, Yamashita Y, Hashimoto N, Kiyono T, Urano T, Furukawa K, Furukawa K. β4GalT6 is involved in the synthesis of lactosylceramide with less intensity than β4GalT5, Glycobiology. 23 (10), 1175-83, 2013, doi: 10.1093/glycob/cwt054

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Rupp A, Cunningham ME, Yao D, Furukawa K, Willison HJ. The effects of age and ganglioside composition on the rate of motor nerve terminal regeneration following antibody-mediated injury in mice, Synapse. 67 (7), 382-9, 2013, doi: 10.1002/syn.21648.

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Matsumoto Y, Zhang Q, Akita K, Nakada H, Hamamura K, Tsuchida A, Okajima T, Furukawa K, Urano T, Furukawa K. Trimeric Tn antigen on syndecan 1 produced by ppGalNAc-T13 enhances cancer metastasis via a complex formation with integrin α5β1 and matrix metalloproteinase 9, J Biol Chem. 288 (33), 24264-76, 2013, doi: 10.1074/jbc.M113.455006.

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Sabit I, Hashimoto N, Matsumoto Y, Yamaji T, Furukawa K, Furukawa K. Binding of a sialic acid-recognizing lectin Siglec-9 modulates adhesion dynamics of cancer cells via calpain-mediated protein degradation, J Biol Chem. 288 (49), 35417-27, 2013, doi: 10.1074/jbc.M113.513192.

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Ogawa M, Nakamura N, Nakayama Y, Kurosaka A, Manya H, Kanagawa M, Endo T, Furukawa K, Okajima T. GTDC2 modifies O-mannosylated α-dystroglycan in the endoplasmic reticulum to generate N-acetyl glucosamine epitopes reactive with CTD110.6 antibody. Biochem Biophys Res Commun. 440 (1), 88-93, 2013, doi: 10.1016/j.bbrc.2013.09.022.

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Kitamura K, Yoshida K, Shiraishi Y, Chiba K, Tanaka H, Furukawa K, Miyano S, Ogawa S, Kunishima S. Normal neutrophil myosin IIA localization in an immunofluorescence analysis can rule out MYH9 disorders, J Thromb Haemost. 11 (11), 2071-3, 2013, doi: 10.1111/jth.12406.

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Furukawa K, Furukawa K, Ohmi Y, Ohkawa Y, Yamauchi Y, Hashimoto N, Tajima O. beta-1, 4 N-acetylgalactosaminyl- transferase 1, 2 (B4GALNT1, 2), In Handbook of Glycosyltransferase and Related Gene, Springer, 2013

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Okajima T and Furukawa K. ST3beta-galactoside alpha-2, 3-sialyltransferase 6 (ST3GALT6), In Handbook of Glycosyltransferase and Related Gene, Springer, 2013

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Furukawa K, Okajima T, Tsuchida A, Furukawa K. a4-galactosyltransferase (A4GALT), In Handbook of Glycosyltransferase and Related Gene, Springer, 2013

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Furukawa K, Ohmi Y, Furukawa K. β3-galactosyltransferase IV (B3GALT4), In Handbook of Glycosyltransferase and Related Gene, Springer, 2013

 

２０１２年

Kondo Y, Ikeda K, Tokuda N, Nishitani C, Ohto U, Akashi-Takamura S, Ito Y, Uchikawa M, Kuroki Y, Taguchi R, Miyake K, Zhang Q, Furukawa K, Furukawa K.TLR4-MD-2 complex is negatively regulated by an endogenous ligand, globotetraosylceramide. Proc Natl Acad Sci U S A. 110(12), 4714-479, 2013 doi: 10.1073/pnas.1218508110. LinkIcon

 

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Yuki N, Takahashi Y, Ihara T, Ito S, Nakajima T, Funakoshi K, Furukawa K, Kobayashi K, Odaka M: Lack of antibody response to Guillain-Barre syndrome-related gangliosides in mice and men after novel flu vaccination. J Neurol Neurosurg Psychiatry. 83(1), 116-117, 2012LinkIcon

 

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Nishiguchi KM, Yasuma TR, Tomida D, Nakamura M, Ishikawa K, Kikuchi M, Ohmi Y, Niwa T, Hamajima N, Furukawa K, Terasaki H: C9-R95X Polymorphism in Patients with Neovascular Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 53(1), 508-12, 2012　doi: 10.1167/iovs.11-8425LinkIcon

 

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Sakaidani Y, Ichiyanagi N, Saito C, Nomura T, Ito M, Nishio Y, Nadano D, Matsuda T, Furukawa K, Okajima T: O-linked-N-acetylglucosamine modification of mammalian Notch receptors by an atypical O-GlcNAc transferase Eogt1. Biochem Biophys Res Commun. 419(1), 14-9,2012.LinkIcon

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Matsumoto Y, Zhang Q, Akita K, Nakada H, Hamamura K, Tokuda N, Tsuchida A, Matsubara T, Hori T, Okajima T, Furukawa K, Urano T, Furukawa K: pp-GalNAc-T13 induces high metastatic potential of murine Lewis lung cancer by generating trimeric Tn antigen. Biochem Biophys Res Commun. 419(1), 7-13, 2012LinkIcon

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Shibuya H, Hamamura K, Hotta H, Matsumoto Y, Nishida Y, Hattori H, Furukawa K, Ueda M, Furukawa K: Enhancement of malignant properties of human osteosarcoma cells with disialyl gangliosides GD2/GD3. Cancer Sci. Epub ahead of print, 2012.LinkIcon

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Kamasaki Y, Nakamura T, Yoshizaki K, Iwamoto T, Yamada A, Fukumoto E, Maruya Y, Iwabuchi K, Furukawa K, Fujiwara T, Fukumoto S. Glycosphingolipids regulate ameloblastin expression in dental epithelial cells. J Dent Res. 91(1), 78-83, 2012. LinkIcon

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Oda M, Kabura M, Takagishi T, Suzue A, Tominaga K, Urano S, Nagahama M, Kobayashi K, Furukawa K, Furukawa K, Sakurai J. Clostridium perfringens Alpha-toxin Recognizes the GM1a/TrkA Complex. J Biol Chem. 2012 Jul 30. [Epub ahead of print] doi: 10.1074/jbc.M112.393801 LinkIcon

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Furukawa K, Hamamura K, Ohkawa Y, Ohmi Y, Furukawa K. Disialyl gangliosides enhance tumor phenotypes with differential modalities. Glycoconj J. 2012 Jul 5. [Epub ahead of print] doi: 10.1007/s10719-012-9423-0 LinkIcon

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Noboru Hashimoto, Kazunori Hamamura, Keiko Furukawa, Kei Kaneko, Norihiro Kotani, Koichi Honke, Koichi Furukawa. Proteomic analysis of ganglioside-associated membrane molecules: Substantial basis for molecular clustering. Proteomics. 12(21), 3154-3163, 2012. doi: 10.1002/pmic.201200279 LinkIcon

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Kurosawa M, Jeyasekharan A, Surmann EM, Hashimoto N, Kurosawa G, Furukawa k, Venlitaraman A, Kurosawa Y. Expression of LY6D is induced at the surface of MCF10A xells by X-ray irradiation. FEBS J. 279(24), 4479-4491, 2012. doi: 10.1111/febs.12034 LinkIcon

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総説
Yuhsuke Ohmi, Yuki Ohkawa, Yoshio Yamauchi, Orie Tajima, Keiko Furukawa, Koichi Furukawa: Essential Roles of Gangliosides in the Formation and Maintenance of Membrane Microdomains in Brain Tissues. Neurochem Res. 37(6), 1185-91, 2012.LinkIcon

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総説
Furukawa K, Ohkawa Y, Yamauchi Y, Hamamura K, Ohmi Y, Furukawa K: Fine tuning of cell signals by glycosylation. J Biochem. 151(6), 573-8, 2012.

 

２０１１年

Shiozuka C, Taguchi A, Matsuda J, Noguchi Y, Kunieda T, Uchio-Yamada K, Yoshioka H, Hamanaka R, Yano S, Yokoyama S, Mannen K, Kulkarni AB, Furukawa K, Ishii S: Increased globotriaosylceramide levels in a transgenic mouse expressing human alpha1,4-galactosyltransferase and a mouse model for treating Fabry disease. J Biochem. 149(2), 161-70, 2011. LinkIcon

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Ohmi Y, Tajima O, Ohkawa Y, Yamauchi Y, Sugiura Y, Furukawa K, Furukawa K. Gangliosides are essential in the protection of inflammation and neurodegeneration via maintenance of lipid rafts: elucidation by a series of ganglioside-deficient mutant mice. J Neurochem. 116(5), 926-935, 2011.
doi: 10.1111/j.1471-4159.2010.07067.x LinkIcon

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Zitman FM, Todorov B, Verschuuren JJ, Jacobs BC, Furukawa K, Furukawa K, Willison HJ, Plomp JJ: Neuromuscular synaptic transmission in aged ganglioside-deficient mice. Neurobiol Aging. 32(1), 157-67, 2011. LinkIcon

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Ikarashi K, Fujiwara H, Yamazaki Y, Goto J, Kaneko K, Kato H, Fujii S, Sasaki H, Fukumoto S, Furukawa K, Waki H, Furukawa K: Impaired hippocampal long-term potentiation and failure of learning in β1,4-N-acetylgalactosaminyltransferase gene transgenic mice. Glycobiology. 21(10), 1373-81, 2011. LinkIcon

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Sakaidani Y, Nomura T, Matsuura A, Ito M, Suzuki E, Murakami K, Nadano D, Matsuda T, Furukawa K, Okajima T: O-Linked-N-acetylglucosamine on extracellular protein domains mediates epithelial cell-matrix interactions. Nat Commun. 13(2), 583, 2011　doi: 10.1038/ncomms1591 LinkIcon

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Miyata M, Kambe M, Tajima O, Moriya S, Sawaki H, Hotta H, Kondo Y, Narimatsu H, Miyagi T, Furukawa K, Furukawa K: Membrane sialidase NEU3 is highly expressed in human melanoma cells promoting cell growth with minimal changes in the composition of gangliosides. Cancer Sci. 102(12), 2139-2149, 2011. LinkIcon

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Ohkawa Y, Ohmi Y, Tajima O, Yamauchi Y, Furukawa K, Furukawa K: Wisp2/CCN5 up-regulated in the central nervous system of GM3-only mice facilitates neurite formation in Neuro2a cells via integrin-Akt signaling. Biochem Biophys Res Commun. 411(3), 483-489, 2011. LinkIcon

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Hayashi K, Ozaki N, Kawakita K, Itoh K, Mizumura K, Furukawa K, Yasui M, Hori K, Yi SQ, Yamaguchi T, Sugiura Y: Involvement of NGF in the rat model of persistent muscle pain associated with taut band. J Pain. 12(10), 1059-1068, 2011. LinkIcon

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Kondo Y, Tokuda N, Furukawa K, Ando R, Uchikawa M, Zhang Q, Xiaoyan F, Furukawa K: Efficient generation of useful monoclonal antibodies reactive with globotriaosylceramide using knockout mice lacking Gb3/CD77 synthase. Glycoconj J. 28(6), 371-84, 2011　doi: 10.1007/s10719-011-9335-4 LinkIcon

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Yamauchi Y, Furukawa K, Hamamura K, Furukawa K: Positive feedback loop between PI3K-Akt-mTORC1 signaling and the lipogenic pathway boosts Akt signaling: induction of the lipogenic pathway by a melanoma antigen. Cancer Res. 71(14), 4989-4997, 2011　doi: 10.1158/0008-5472.CAN-10-4108 LinkIcon

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Hamamura K, Tsuji M, Hotta H, Ohkawa Y, Takahashi M, Shibuya H, Nakashima H, Yamauchi Y, Hashimoto N, Hattori H, Ueda M, Furukawa K, Furukawa K: Functional activation of Src family kinase yes protein is essential for the enhanced malignant properties of human melanoma cells expressing ganglioside GD3. J Biol Chem. 286(21), 18526-18537, 2011　doi: 10.1074/jbc.M110.164798 LinkIcon

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Moriya H, Uchida K, Okajima T, Matsuda T, Nadano D: Secretion of three enzymes for fatty acid synthesis into mouse milk in association with fat globules, and rapid decrease of the secreted enzymes by treatment with rapamycin. Arch Biochem Biophys. 508(1), 87-92, 2011. LinkIcon

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総説
Koichi Furukawa, Yuhsuke Ohmi, Yuki Ohkawa, Noriyo Tokuda, Yuji Kondo, Orie Tajima, Keiko Furukawa: Regulatory mechanisms of nervous systems with glycosphingolipids. Neurochem Res. 36(9), 1578-1586, 2011.
DOI: 10.1007/s11064-011-0494-2 LinkIcon

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総説
Okajima T: Specific O-glycosylation modifying epidermal growth factor domains. Seikagaku. 83(9), 813-821, 2011. Japanese. LinkIcon

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総説
Furukawa K, Ohmi Y, Ohkawa Y, Tokuda N, Tajima O, Furukawa K: Molecular mechanisms for the regulation of nervous systems with glycosphingolipids. Seikagaku. 83(3), 169-173, 2011. Review. Japanese.

 

２０１０年

Zitman FM, Todorov B, Furukawa K, Furukawa K, Willison HJ, Plomp JJ: Total ganglioside ablation at mouse motor nerve terminals alters neurotransmitter release level. Synapse. 64(4), 335-338, 2010. LinkIcon

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Matsumoto Y, Kobata T, Odaka M, Furukawa K, Hirata K, Yuki N: BAFF aids generation of IgG anti-ganglioside antibodies in response to Campylobacter jejuni lipo-oligosaccharide. J Neuroimmunol. 218(1-2), 67-72, 2010. LinkIcon

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Tajima O, Egashira N, Ohmi Y, Fukue Y, Mishima K, Iwasaki K, Fujiwara M, Sugiura Y, Furukawa K, Furukawa K: Dysfunction of muscarinic acetylcholine receptors as a substantial basis for progressive neurological deterioration in GM3-only mice. Behav Brain Res. 206(1), 101-108, 2010. LinkIcon

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Dong Y, Ikeda K, Hamamura K, Zhang Q, Kondo Y, Matsumoto Y, Ohmi Y, Yamauchi Y, Furukawa K, Taguchi R, Furukawa K: GM1  / GD1b / GA1 synthase expression results in the reduced cancer phenotypes with modulation of composition and raft-localization of gangliosides in a melanoma cell line. Cancer Sci. 101(9), 2039-2047, 2010. LinkIcon

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Ohkawa Y, Miyazaki S, Hamamura K, Kambe M, Miyata M, Tajima O, Ohmi Y, Yamauchi Y, Furukawa K, Furukawa K: Ganglioside GD3 enhances adhesion signals and augments malignant properties of melanoma cells by recruiting integrins to glycolipid-enriched microdomains. J Biol Chem. 285(35), 27213-27223, 2010. LinkIcon

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McGonigal R, Rowan EG, Greenshields KN, Halstead SK, Humphreys PD, Rother RP, Furukawa K, Willison HJ: Anti-GD1a antibodies activate complement and calpain to injure distal motor nodes of Ranvier in mice. Brain. 133(Pt 7), 1944-1960, 2010. LinkIcon

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Inoko E, Nishiura Y, Tanaka H, Takahashi T, Furukawa K, Kitajima K, Sato C: Developmental stage-dependent expression of an alpha2,8-trisialic acid unit on glycoproteins in mouse brain. Glycobiology. 20(7), 916-928, 2010. LinkIcon

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Hino S, Umeda F, Inumaru S, Aoki N, Sato C, Okajima T, Nadano D, Matsuda T: IgG2 dominancy and carbohydrate recognition specificity of C3H/He mouse antibodies directed to cross-reactive carbohydrate determinants (CCDs) bearing beta-(1,2)-xylose and alpha-(1,3)-fucose. Immunol Lett. 133(1), 28-34, 2010. LinkIcon

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総説
Furukawa K, Hamamura K, Ohkawa Y, Furukawa K: [Drug discovery sciences in Japan with focus on molecular-targeted drugs]. Nippon Rinsho. 68(10), 1797-1802, 2010, Review. Japanese. LinkIcon

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総説
Sakaidani Y, Furukawa K, Okajima T: O-GlcNAc modification of the extracellular domain of Notch receptors. Methods in Enzymol. 480:355-373, 2010, Review. LinkIcon

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総説
Okajima, T., Furukawa, K., Sakaidani, Y: O-GlcNAc modification of the extracellular domain of Notch receptors. Trends in Glycoscience and Glycotechnology. 22(127), 247-255, 2010. LinkIcon

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総説
Stanley P, Okajima T: Roles of glycosylation in Notch signaling. Curr Top Dev Biol. 92,131-164, 2010, Review. LinkIcon

 

２００９年

Tajima O, Egashira N, Ohmi Y, Fukue Y, Mishima K, Iwasaki M, Fujiwara M, Sugiura Y, Furukawa K, Furukawa K. Reduced motor and sensory functions and emotional response in GM3-only mice: emeregence from early stage of life and exacerbation with aging. Behav Brain Res. 198(1), 74-82, 2009. LinkIcon

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Kondo Y, Tokuda N, Fan X, Yamashita T, Honke K, Takematsu H, Togayachi A, Ohta M, Kotzusumi Y, Narimatsu H, Tajima O, Furukawa K, Furukawa K. Glycosphingolipids are not pivotal receptors for Subtilase cytotoxin in vivo: sensitivity analysis with glycosylation-defective mutant mice. Biochem Biophys Res Commun. 378(2), 179-181, 2009. LinkIcon

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Edina Silajdzic, Hugh J. Willison, Koichi Furukawa, and Susan C. Barnett1: In Vitro Analysis of Glial Cell Function in Ganglioside-deficient Mice. J Neurosci Res. 87(11), 2467-83, 2009. LinkIcon

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Oikawa N, Yamaguchi H, Ogino K, Taki T, Yuyama K, Yamamoto N, Shin RW, Furukawa K, Yanagisawa K: Gangliosides determine the amyloid pathology of Alzheimer's disease. Neuroreport. 20(12), 1043-6, 2009. LinkIcon

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Greenshields KN, Halstead SK, Zitman FM, Rinaldi S, Brennan KM, O'Leary C, Chamberlain LH, Easton A, Roxburgh J, Pediani J, Furukawa K, Furukawa K, Goodyear CS, Plomp JJ, Willison HJ. The neuropathic potential of anti-GM1 autoantibodies is regulated by the local glycolipid environment in mice. J Clin Invest. 119(3):595-610, 2009. LinkIcon

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Ohmi Y, Tajima O, Ohkawa Y, Mori A, Sugiura Y, Furukawa K, Furukawa K: Gangliosides play pivotal roles in the regulation of complement systems and in the maintenance of integrity in nerve tissues. Proc Natl Acad Sci U S A. 106(52), 22405-10, 20

09.（＊GCOEリサーチアワード受賞）LinkIcon

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Ban R, Matsuzaki H, Akashi T, Sakashita G, Taniguchi H, Park SY, Tanaka H, Furukawa K, Urano T: Mitotic regulation of the stability of microtubule plus-end tracking protein EB3 by ubiquitin ligase SIAH-1 and Aurora mitotic kinases. J Biol Chem. 284(41), 28367-81, 2009. LinkIcon

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Okuda T, Furukawa K, Nakayama K: A novel, promoter-based, target-specific assay identifies 2-deoxy-D-glucose as an inhibitor of globotriaosylceramide biosynthesis. FEBS J. 276(18), 5191-5202, 2009. LinkIcon

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Li Y, Thapa P, Hawke D, Kondo Y, Furukawa K, Furukawa K, Hsu FF, Adlercreutz D, Weadge J, Palcic MM, Wang PG, Levery SB, Zhou D. Immunologic glycosphingolipidomics and NKT cell development in mouse thymus. J Proteome Res. 8(6), 2740-2751, 2009. LinkIcon

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総説
Furukawa K, Tsuchida A, Okajima T, Furukawa K.: Glycoconjugate glycosyltransferases. Glycoconj J. 26(8), 987-998, 2009. LinkIcon